Estimating Health-State Utility for Economic Models in Clinical Studies
This method provides guidance on how to collect and analyze data about patients' quality of life (called health-state utility) during clinical studies, so that these data can be used in economic models to assess the value of treatments.
At a glance
Use when
Conducting economic evaluations alongside clinical trials; estimating quality-adjusted life years (QALYs); developing cost-utility models
Avoid when
Utility measurement is not feasible; no validated instruments are available for the population; when only clinical effectiveness data are needed
Inputs
Clinical study data, patient-reported outcomes, utility instruments (e.g., EQ-5D, SF-6D)
Outputs
Health-state utility estimates suitable for use in economic models
How it works
Developed by the ISPOR Good Research Practices Task Force, this method outlines standardized approaches for the collection, analysis, and interpretation of health-state utility data within clinical trials and other clinical studies, ensuring their appropriate integration into economic models such as cost-utility analyses.
- HTA domains
- Clinical Effectiveness, Costs & Economic Evaluation, Patient and Social Aspects
- Categories
- HRQoL
- Assumptions
- Utility values can be reliably measured in clinical settings; patient-reported data reflect societal or patient preferences; utility instruments are valid and responsive
- Strengths
- Provides standardized, consensus-based guidance; enhances comparability across studies; supports robust economic evaluations
- Limitations
- May require adaptation to local settings; assumes availability of appropriate utility instruments; implementation depends on study design and data quality
- Also known as
- ISPOR Health-State Utility Estimation Guidelines
Questions this answers
- › How should health-state utility data be collected in clinical studies?
- › What instruments are recommended for utility measurement?
- › How should utility data be analyzed for use in economic models?
- › What are best practices for linking clinical outcomes to utility values?
- › How can missing data and biases in utility estimation be addressed?
- › What considerations are important when using utility data in model-based economic evaluations?
References & sources
Related methods
Similar by meaning
Beta record. Based on the original catalogue summary; primary-source enrichment pending.