EQ-5D-Y-3L International Valuation Protocol
This method explains how to measure health-related quality of life for children using the EQ-5D-Y-3L questionnaire. It helps researchers create value sets for use in cost-utility analyses by combining two techniques: one to compare health states and another to anchor them on a scale where full health is 1 and dead is 0.
At a glance
Use when
Developing country-specific value sets for pediatric health-related quality of life for use in economic evaluations, especially when conducting cost-utility analyses involving children.
Avoid when
When a ready-to-use pediatric value set already exists for the target population; when working with very young children who cannot reliably complete DCE or cTTO tasks.
Inputs
Responses from discrete choice experiments and composite time-trade-off tasks completed by respondents (adults or children) evaluating EQ-5D-Y-3L health states.
Outputs
Country-specific value sets for EQ-5D-Y-3L health states, suitable for use in cost-utility analysis.
How it works
The EQ-5D-Y-3L International Valuation Protocol outlines a standardized approach to generate country-specific value sets for the EQ-5D-Y-3L, a pediatric adaptation of the EQ-5D-3L. It uses discrete choice experiments (DCE) to estimate the relative severity of health states across five dimensions, and composite time-trade-off (cTTO) to anchor these values on a scale where Full Health = 1 and Dead = 0. The protocol was developed following a research program addressing key methodological questions about valuation in pediatric populations.
- HTA domains
- Clinical Effectiveness, Costs & Economic Evaluation, Patient and Social Aspects
- Assumptions
- Health state values for children may differ from adults and require separate valuation; societal preferences can be reliably captured using DCE and cTTO; the cTTO can appropriately anchor child health state values on a 0–1 scale with Dead as 0.
- Strengths
- Provides a standardized, internationally applicable method for generating pediatric EQ-5D-Y-3L value sets,Combines DCE for relative severity with cTTO for absolute valuation, ensuring values are suitable for cost-utility analysis,Based on empirical research addressing key methodological challenges in pediatric valuation
- Limitations
- Does not resolve whether children or adults should provide the values,cTTO may be cognitively challenging for younger respondents,Cross-cultural differences in interpretation of health states may affect comparability
- Also known as
- EQ-5D-Y-3L Valuation Protocol, International Valuation Protocol for EQ-5D-Y-3L
Questions this answers
- › Do we need separate value sets for children's health states, or can adult values be used?
- › Should health state values for children be elicited from children or adults?
- › Which valuation methods are appropriate for anchoring child health states on a 0 (Dead) to 1 (Full Health) scale?
- › How can relative importance of EQ-5D-Y-3L dimensions and levels be measured?
- › How can consistent and comparable value sets for pediatric populations be generated across countries?
- › What protocol enables the use of EQ-5D-Y-3L in cost-utility analyses?
References & sources
Similar by meaning
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