Danish value sets for the EORTC QLU-C10D (cancer utility)
This value set provides Danish-specific utility weights for the EORTC QLU-C10D, a tool that measures health-related quality of life in cancer patients. It allows researchers to convert patient-reported outcomes into utility scores used in economic evaluations, reflecting how different cancer-related symptoms affect overall well-being from the perspective of the Danish general population.
At a glance
Use when
Conducting cost-utility analyses in oncology within the Danish healthcare context; translating EORTC QLQ-C30 or QLU-C10D patient-reported outcomes into quality-adjusted life years (QALYs) using Danish preference weights.
Avoid when
When population preferences from another country are required; when using non-cancer populations or non-oncology conditions where the QLU-C10D may not be valid; when patient-based weights are preferred over general population weights.
Inputs
Health state descriptions based on the 10 dimensions of the EORTC QLU-C10D (e.g., physical functioning, pain, role functioning, fatigue, etc.) at specific severity levels.
Outputs
Utility scores (preference weights) for cancer-related health states, anchored on a scale where 1 = full health and 0 = death, derived from Danish population preferences.
How it works
Danish utility weights for the EORTC QLU-C10D were derived using a discrete choice experiment (DCE) with 1001 representative adults from the Danish general population. Participants responded to 16 choice sets based on the 10 dimensions of the QLU-C10D. Conditional logistic regression was used to estimate utility weights, with corrections applied for non-monotonicity. The resulting value set enables the calculation of health state utilities for cost-utility analyses in oncology, specific to Danish population preferences.
- HTA domains
- Costs & Economic Evaluation, Patient and Social Aspects
- Categories
- HRQoL
- Assumptions
- Respondents' choices in the DCE reflect consistent preferences over health states; the QLU-C10D dimensions adequately capture relevant aspects of cancer-related quality of life; population representativeness allows generalization to the broader Danish population.
- Strengths
- Based on a large, representative sample of the Danish general population (n = 1001),Follows standardized methodology for DCE-based value set development,Provides country-specific utility weights for a cancer-specific multi-attribute utility instrument,Includes correction for non-monotonicity, enhancing model validity
- Limitations
- Non-monotonicity observed in some dimensions (sleep disturbances, lack of appetite, bowel problems), though not statistically significant,Web-based survey may exclude certain population groups with limited digital access,Weights reflect general population preferences, which may differ from patient perspectives
- Also known as
- Danish EORTC QLU-C10D value set, Danish utility weights for QLU-C10D
Questions this answers
- › What is the impact of different cancer-related health states on quality of life from the perspective of the Danish general population?
- › How can EORTC QLQ-C30 data be transformed into utility scores for economic evaluation in Denmark?
- › Which symptoms have the largest negative impact on health utility among Danish respondents?
- › Are the severity levels of symptoms in the QLU-C10D perceived monotonically by the Danish population?
- › Can the EORTC QLU-C10D be used to support cost-utility analyses in Danish healthcare decision-making?
- › How do Danish utility weights for cancer-related health states compare to those from other countries?
References & sources
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