ASCO Value Framework (revised)
The ASCO Value Framework (revised) helps patients and doctors compare cancer treatments by looking at how well they work, their side effects, and their cost. It gives a score based on what matters most to the patient, like living longer or having fewer symptoms, and includes financial impact so patients can make informed choices together with their doctor.
At a glance
Use when
Comparing value of cancer treatment options within a clinical trial context, supporting patient-centered decision-making, evaluating trade-offs between clinical benefit, toxicity, and cost in oncology.
Avoid when
Conducting cross-trial comparisons, assessing non-oncology treatments, when patient preference elicitation is not feasible, or when comprehensive quality-of-life or societal impacts are required.
Inputs
Clinical trial data on efficacy (e.g., survival, response), toxicity profiles, symptom palliation, patient preferences (via weighting), and treatment costs.
Outputs
Net Health Benefit (NHB) score, adjusted for patient preferences, and comparative cost information for treatment regimens.
How it works
The ASCO Value Framework calculates a Net Health Benefit (NHB) score by integrating clinical benefit, toxicity, and symptom palliation data from comparative clinical trials. The NHB is adjusted based on patient preferences through weighted inputs, allowing personalized valuation. Two versions exist: one for advanced cancer and another for adjuvant (potentially curative) settings. Cost information is presented alongside the NHB to inform financial considerations. The framework relies on high-quality evidence, preferably from randomized controlled trials, and aims to support shared decision-making. Future iterations aim to enable cross-trial comparisons.
- HTA domains
- Clinical Effectiveness, Costs & Economic Evaluation, Patient and Social Aspects
- Categories
- AppraisalCost-effectiveness Modelling
- Assumptions
- Clinical trial data are reliable and comparable; patient preferences can be meaningfully quantified through weighting; value is a function of clinical benefit, toxicity, symptom control, and cost; oncologists and patients engage in shared decision-making.
- Strengths
- Promotes shared decision-making between oncologists and patients,Incorporates patient preferences into treatment valuation,Transparent method for comparing clinical benefits and harms,Includes financial impact of treatments,Based on high-quality clinical evidence from randomized trials
- Limitations
- Limited to within-trial comparisons; does not support cross-trial analyses in current form,Does not account for treatment convenience or impact on daily life,Quality of life and non-clinical factors are not fully integrated,Weighting system may oversimplify patient preferences,Primarily applicable to oncology; not generalizable to other disease areas
- Also known as
- ASCO Value Framework, ASCO Value in Cancer Care Framework, ASCO Value Framework (revised 2016)
Questions this answers
- › How effective is a cancer treatment in improving survival or disease control?
- › What are the side effects and toxicities associated with a treatment regimen?
- › How does a treatment impact symptom burden and palliation?
- › What is the financial cost of a treatment to the patient?
- › How can treatment value be personalized based on patient preferences?
- › How do different cancer treatments compare in terms of overall value?
References & sources
Similar by meaning
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